From veterinary validation to human trials
Why melanoma first
Melanoma incidence keeps climbing, the diagnosed population is large, and the market is on track to roughly double — a clear first indication for intratumoral delivery.
Strong Phase I results at Moffitt Cancer Center support the intratumoral electroporation approach in human melanoma.
Source: NCI SEER prevalence estimate.
Publications & resources
Thermal-assisted in vivo gene electrotransfer
Hover to read the abstractEstablishes that moderate, controlled heat assists gene electrotransfer in vivo — the thermal envelope within which IntelliPulse operates.
Download PDFEdelblute — Moderate heat and squamous cell carcinoma
Hover to read the abstractDemonstrates that moderate heat combined with electroporation enhances response in squamous cell carcinoma models.
Download PDFAtkins — Impedance measurement during electroporation
Hover to read the abstractFoundational work on measuring tissue impedance during pulse delivery — the basis of real-time treatment feedback.
Download PDFConnolly — Impedance-sensing electrode design
Hover to read the abstractElectrode geometry and sensing architecture enabling impedance capture without compromising field uniformity.
Download PDFDonate — Thermal effects in vitro, Bioelectrochemistry
Hover to read the abstractIn vitro measurement of thermal load across pulse parameters, informing the low-voltage design philosophy.
Download PDFEdelblute — HBsAg gene therapy vaccine study
Hover to read the abstractGene electrotransfer of a hepatitis B surface antigen construct, showing durable expression from a single session.
Download PDFImpedance Paper I — Real-time tissue feedback
Hover to read the abstractEstablishes impedance as a real-time confirmation that therapeutic delivery has occurred in the target tissue.
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